Evaluation of the efficacy and safety of colchicine in the prevention for post-CABG atrial fibrillatio

Phase 2

Recruiting

• Conditions: Atrial Fibrillation.; Unspecified atrial fibrillation; I48.91

• Registration Number: IRCT20200328046886N6
• Lead Sponsor: Mazandaran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 26 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 172

Inclusion Criteria

Patient between 18_80 years old
Patient with CAD and candidate for CABG

Exclusion Criteria

Preoperative AF
Patients with pacemakers
Patient with Clcr<30ml/min
Severe hepatic insufficiency or transaminase level more than 3 times higher than normal
Breastfeeding or pregnancy
Colchicine intolerance or allergy
Lack of patients consent to participate in study
Presences of sick Sinus syndrom
Previous cardiac rhythm disorder,conduction blocks of any degree
Co administration with strong pgp and 3A4 inhibitors (voiconazol,ketoconazole,fluconazole,itraconazole,clarithromycin,etc.)
Taking anti arrhythmic medicines except beta blockers during past months of surgery

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Atrial fibrilation. Timepoint: Monitoring up to 14 days. Method of measurement: ECG.

Secondary Outcome Measures

Name	Time	Method
Duration of hospitalization. Timepoint: From CABG surgery to hospital discharge. Method of measurement: Monitoring.;Inflammatory factors (CRP,IL6). Timepoint: Day 1 and day 7. Method of measurement: Blood test.