The DEPTH Project: Detection, Evaluation, and Psychological Therapy for Health

Recruiting

• Conditions: ltra-high risk for the development of a psychotic disorder; Ultra-high risk for the development of a psychotic disorder; Mental Health - Psychosis and personality disorders

• Registration Number: ACTRN12606000101583
• Lead Sponsor: Prof. Mike Startup, University of Newcastle

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-03-15
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 78

Inclusion Criteria

reside within the boundaries of the Hunter New England Health Area or the former Mid-Western region of the Greater Western Area Health Service, meet criteria for one or more of 3 ‘at-risk mental states’ (ARMS). These three groups are operationally defined as follows: Group A (state and trait risk factors): A combination of a first-degree relative with a history of any psychotic disorder, or the patient meets DSM-IV criteria for a diagnosis of schizotypal personality disorder, and any change in mental state or functioning which has resulted in a loss of at least 30% on the Global Assessment of Functioning scale for at least one month. Group B (attenuated psychotic symptoms): The person has developed one or more prodromal symptoms which represent a change in their functioning, different from their normal personality, and which occur with a frequency of at least several times a week and have been occurring for at least one week. The symptoms include ideas of reference, odd beliefs or magical thinking, perceptual disturbance, suspiciousness or paranoid thinking, and behaviour that is odd, eccentric or peculiar. The symptoms must deviate significantly from normal, as defined by ratings in the prodromal range on the Comprehensive Assessment of At Risk Mental States (CAARMS). Group C (transient psychotic symptoms): The person has a history during the previous year of brief limited intermittent psychotic symptoms (BLIPS) lasting less than one week before resolving spontaneously. The symptoms are defined by the presence of one or more ratings in the psychotic range on the CAARMS positive items: disorders of thought content, perceptual abnormalities, disorganised speech.

Exclusion Criteria

Meet criteria for a past or current DSM-IV psychotic disorder, have previously been prescribed anti-psychotic medication, have an organic mental disorder or intellectual disabilities, are at serious suicidal or homicidal risk (they will be eligible for inclusion once this risk has resolved), have an inadequate command of the English language.

Study & Design

• Study Type: Interventional
• Study Design: Not specified