The relation between neurodegeneration and other pathology in multiple sclerosis: an in vivo MRI study

Completed

• Conditions: MS; multiple sclerosis; 10003816; 10012303

• Registration Number: NL-OMON36150
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 85

Inclusion Criteria

- Age 18-65 years
- Clinically definite MS (based on Polman criteria, 2005)
- Need to meet the safety criteria to undergo an MRI examination

Exclusion Criteria

For all participants:
- History of drug abuse
- Psychiatric disease
- Claustrophobia
- Pregnancy
- Foreign non MR compatible metal objects in the body
- Foreign metal objects in or close to the head;Aditionally for the patients:
- Other neurological disorders besides MS
- Relapses and/or steroid treatment in the four weeks prior to the examination;Additionally for the healthy controls:
- Neurological disorders

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Global and local atrophy measures will be obtained from high resolution<br /><br>T1-weighted images. Conventional MR images of the brain and spinal cord, and 3D<br /><br>DIR images will be used to detect and classify MS lesions. Advanced MRI<br /><br>techniques, namely DTI and T1 relaxation-time mapping, will be used to quantify<br /><br>tissue damage in normal appearing brain tissue, and relations between these<br /><br>parameters will be assessed.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>