NL-OMON47032
Completed
Not Applicable
Impact of dementia-related neurodegeneration on pain processing - Pain processing in dementia
Huisartsgeneeskunde0 sites125 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Alzheimer desease
- Sponsor
- Huisartsgeneeskunde
- Enrollment
- 125
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •In order to be eligible to participate in this study, a subject must meet all of the following criteria:;All subjects:
- •\- Age from 55 \* 85 yr
- •\- Willingness to cooperate and sign written informed consent \* or proxy consent with assent of participating subject;Normal Healthy Controls (CP):
- •\- MMSE scores between 27\-30
- •\- Without subjective memory complaints;Alzheimers\*s disease dementia (AD):
- •\- Diagnosis of probable AD according to the Alzheimer\*s disease and Related Disorders Associations (NINCDS\-ADRDA) criteria and NIA\-AA guidelines ( McKhann et al. 2011\).;Frontotemporal dementia (FTD):
- •\- Diagnosis of behavioral variant FTD (FTD\-b) according to the revised consensus criteria (Rascovsky et al. 2011\).
- •\- Diagnosis of a subtype of FTD of Primary Progressive Aphasia (PPA), divided into Semantic Dementia (SD), Progressive Nonfluent Aphasia (PNFA) and LPA due to FTD (Gorno\-Tempini et al. 2011\). ;Vascular dementia (VD):
- •\- Diagnosis of probable VD according to the NINDS\-AIREN (National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et l\*Enseignement en Neurosciences) guidelines (Roman et al. 1993\).
Exclusion Criteria
- •All subjects:
- •\- History of major psychiatric illness
- •\- Medications which may affect pain processing (selective serotonin re\-uptake inhibitors, opioids, other analgesics)
- •\- Contraindications for MR\-measurements (e.g. cochlear implants and most permanent pacemakers, red tattoos);Normal healthy Controls:
- •\- abnormal results on neuropsychological tests
- •\- subjective memory complaints;All patients:
- •\- Cognitive deficits could be explained by non\-neurodegenerative condition (e.g. stroke, neoplasm, head injury, hydrocephalus or other medical condition)
Outcomes
Primary Outcomes
Not specified
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