When and how to remove prophylactic abdominal drains after elective liver resection: a retrospective observational study evaluating drain removal on the third and first postoperative day

Not Applicable

• Conditions: Patients who underwent open liver resection at the University of Tokyo Hospital

• Registration Number: JPRN-UMIN000030518
• Lead Sponsor: Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo

Brief Summary

The median duration of the postoperative hospital stay was shorter in the POD 3 group than in the control group (P<0.0001). The incidence of drain infection was lower in the POD 3 group (1.2%) than in the control group (5.7%). Meanwhile, the incidences of bile leakage and complications were higher in the POD 1 group than in the POD 3 group. However, the incidences were almost the same when patients whose drains were actually removed on the predefined POD were compared.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-12-22
• Study Completion: 2018-12-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 323

Inclusion Criteria

Not provided

Exclusion Criteria

Patients with any of the following were excluded: a need for bilioenteric reconstruction; required resection of another organ (except cholecystectomy); other malignant disease outside the liver; an indocyanine green retention rate at 15 minutes 20% or more; and severe co-morbidity, such as renal dysfunction (estimated glomerular filtration rate of 20 mL per min per 1.73 m2 or less), cardiovascular disease (necessitating intervention or an ejection fraction of no more than 50 percent), or a respiratory disorder (vital capacity below 60 percent or forced expiratory volume in 1 s of less than 50 percent).

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The length of postoperative hospital stay

Secondary Outcome Measures

Name	Time	Method
Incidences of major complications such as drain infection, bile leakage, and percutaneous puncture for fluid collection. The proportion of patients with complications classified as grade III or above according to the Clavien-Dindo classification was also evaluated.