Cerebrospinal fluid concentrations of polyols following traumatic brain injury

• Conditions: neurotrauma; Traumatic brain injury; 10018424; 10022114; 10029305

• Registration Number: NL-OMON56843
• Lead Sponsor: Amsterdam UMC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

• Adult (aged at least 18 years)
• Clinical diagnosis of moderate to severe TBI, classified by Glasgow Coma
Scale (GCS), with GCS <9 indicating severe TBI and GCS 9-12 moderate TBI
• Extra ventricular drain in situ

Exclusion Criteria

• Admission to the ICU is solely for the purposes of palliative care or
confirmation of organ donation
• Advanced care directive or previously stated wish not to be included in
research activities
• Past medical history of diabetes mellitus
• HbA1c >= 6.5%

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>i. CSF polyol (sorbitol and fructose) concentrations</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>i. CSF polyol : plasma glucose ratios.<br /><br>ii. CSF polyol : CSF glucose ratios.<br /><br>iii. Plasma and CSF neuroinflammatory markers: S100-beta, neuron specific<br /><br>enolase, neurofilament light, IL-6, TNF-alpha, Il-10, interferon-gamma.</p><br>