Comparative plasma and cerebrospinal fluid pharmacokinetics of paracetamol following intravenous and oral administratio

Phase 4

Completed

• Conditions: Analgesic concentrations of paracetamol; Anaesthesiology - Pain management

• Registration Number: ACTRN12615000322538
• Lead Sponsor: Royal Melbourne Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-04-09
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

1. aged 18 years and over
2. presenting for elective surgery under spinal anaesthesia
3. able to communicate in English
4. no contraindication to paracetamol
5. no paracetamol within previous 12 hours

Exclusion Criteria

1. aged <18 years
2. not planned for spinal anaesthesia
3. unable to communicate in English
4. contraindication to paracetamol
5. paracetamol within previous 12 hours

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cerebrospinal fluid concentration of paracetamol[0, 15, 30, 45, 60, 90, 120, 180, 240 and 360 minutes following paracetamol administration]

Secondary Outcome Measures

Name	Time	Method
Plasma concentration of paracetamol[0, 15, 30, 45, 60, 90, 120, 180, 240 and 360 minutes following paracetamol administration]