A Study Comparing Doxycycline and Levofloxacin for Treating COPD Exacerbations

Not Applicable

Not yet recruiting

• Conditions: COPD
• Interventions: Drug: Doxycycline; Drug: Levofloxacin

• Registration Number: NCT06915688
• Lead Sponsor: Amina Aslam

Brief Summary

This study will include patients with chronic obstructive pulmonary disease (COPD) who present with an acute exacerbation. Participants will be randomly assigned to receive either doxycycline or levofloxacin for 5 days. The aim is to compare how effective each antibiotic is in improving symptoms after 2 days of treatment.

Detailed Description

This randomized controlled trial will evaluate the effectiveness of two antibiotics-doxycycline (a tetracycline) and levofloxacin (a fluoroquinolone)-in the treatment of acute exacerbations of chronic obstructive pulmonary disease. Participants will be assigned to one of the two treatment groups and will receive either doxycycline 100 mg twice daily or levofloxacin 500 mg once daily for 5 days. The primary outcome is clinical cure. This will be evaluated 2 days after completion of antibiotic therapy, based on symptom resolution and laboratory markers.

Study Timeline

• Status Verified: 2025-03
• Study First Submitted: 2025-03-19
• Study First Submitted QC: 2025-04-04
• Last Update Submitted: 2025-04-04
• Study First Posted: 2025-04-08
• Last Update Posted: 2025-04-08
• Study Start: 2025-04-15
• Primary Completion: 2025-07-28
• Study Completion: 2025-07-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 188

Inclusion Criteria

• diagnosed cases of COPD Exacerbation of COPD Able to provide Written consent No anti biotic taken with in past 4 weeks

Exclusion Criteria

• hypersensitivity to any drugs Pneumonia evidence on xray/ hrct chest Any other pulmonary condition e.g asthma Pregnancy/breast feeding Taking treatment for other active infections

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Arm 1	Doxycycline	Doxycycline will be given to this group
Arm 2	Levofloxacin	Levofloxacin in copd patients

Primary Outcome Measures

Name	Time	Method
Clinical Cure Rate	7 days	1. A decrease in the respiratory rate by 20% from the baseline measurement.; 2. Restoration of Oxygen saturation levels to within the range of 88-92% on room air.; 3. CRP\<10ng/ml; 4. decrease in sputum quantity; 5. reduction in body temperature below 99•F; 6. TLC \<11,000

Trial Locations

Locations (1)

General hospital; 🇵🇰 Lahore, Pakistan