A prospective randomized controlled trial to investigate the effect of early administration of antibiotics for patients with suspected sepsis

Completed

• Conditions: bloodpoisoning; sepsis; 10004018

• Registration Number: NL-OMON43665
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 2800

Inclusion Criteria

1) in the history signs of an infection and a body temperature of > 38 degrees celcius or < 36 degrees celcius AND 2) at least of one the following criteria: A respiratory rate of > 20/min; A heart rate of > 90/min ;

Exclusion Criteria

- age <18 years
- known severe allergic reaction to ceftriaxone or to other beta-lactam antibiotics
- pregnancy
- Orthopaedic patients with prosthetic infections (e.g knee, hip)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>reduction of mortality in patients with sepsis </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Length of hospital stay , Length of ICU stay if applicable<br /><br>- Door to needle time in control group<br /><br>- Adverse events in the intervention group and the control group<br /><br>- Quality of life after one month after discharge from the hospital<br /><br>-- Number of blood cultures with Bacteria resistant to ceftriaxone<br /><br>- Hour of transfer to the intensive care, medium care or to a normal ward</p><br>