Developing Advanced MRI Methods for Detecting the Impact of Nutrients on Infant Brain Development
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- Magnetic Resonance Imaging to measure of brain metabolites, brain structures and brain function
研究概览
简要总结
The purpose is to study the effect of infant nutrition on brain development, as measured using Magnetic Resonance (MR) techniques. The investigators will collect detailed information about the diet of each of the infants, and seek to correlate this information with multiple MR measurements, including structural imaging, diffusion imaging, and functional connectivity. The MR scans will be performed at birth and 3 months of age. Dietary information collected will include detailed food diaries describing the feeding habits of the infants, and food frequency questionnaires to characterize the diet of the mother.
详细描述
The purpose is to study the effect of infant nutrition on brain development, as measured using Magnetic Resonance (MR) techniques. The investigators will collect detailed information about the diet of each of the infants, and seek to correlate this information with multiple MR measurements, including structural imaging, diffusion imaging, and functional connectivity. The MR scans will be performed at birth and 3 months of age. Dietary information collected will include detailed food diaries describing the feeding habits of the infants, and food frequency questionnaires to characterize the diet of the mother.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 4 Months（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •full-term babies whose mothers have no known medical conditions or complications during pregnancy.
排除标准
- •preterm babies
- •babies whose mothers have significant medical conditions and/or significant complications during pregnancy.
结局指标
主要结局
Magnetic Resonance Imaging to measure of brain metabolites, brain structures and brain function
时间窗: Infants receive an MRI scan at less than 2 weeks of age
次要结局
- Nutritional analysis of mothers diet using a food frequency questionnaire(Mothers fill out questionnaire at three months after enrollment into the study)
研究者
Ellen Grant
MD
Boston Children's Hospital