Developing Advanced MRI Methods for Detecting the Impact of Nutrients on Infant Brain Development
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Infant Development
- Sponsor
- Boston Children's Hospital
- Enrollment
- 130
- Locations
- 1
- Primary Endpoint
- Magnetic Resonance Imaging to measure of brain metabolites, brain structures and brain function
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The purpose is to study the effect of infant nutrition on brain development, as measured using Magnetic Resonance (MR) techniques. The investigators will collect detailed information about the diet of each of the infants, and seek to correlate this information with multiple MR measurements, including structural imaging, diffusion imaging, and functional connectivity. The MR scans will be performed at birth and 3 months of age. Dietary information collected will include detailed food diaries describing the feeding habits of the infants, and food frequency questionnaires to characterize the diet of the mother.
Detailed Description
The purpose is to study the effect of infant nutrition on brain development, as measured using Magnetic Resonance (MR) techniques. The investigators will collect detailed information about the diet of each of the infants, and seek to correlate this information with multiple MR measurements, including structural imaging, diffusion imaging, and functional connectivity. The MR scans will be performed at birth and 3 months of age. Dietary information collected will include detailed food diaries describing the feeding habits of the infants, and food frequency questionnaires to characterize the diet of the mother.
Investigators
Ellen Grant
MD
Boston Children's Hospital
Eligibility Criteria
Inclusion Criteria
- •full-term babies whose mothers have no known medical conditions or complications during pregnancy.
Exclusion Criteria
- •preterm babies
- •babies whose mothers have significant medical conditions and/or significant complications during pregnancy.
Outcomes
Primary Outcomes
Magnetic Resonance Imaging to measure of brain metabolites, brain structures and brain function
Time Frame: Infants receive an MRI scan at less than 2 weeks of age
Secondary Outcomes
- Nutritional analysis of mothers diet using a food frequency questionnaire(Mothers fill out questionnaire at three months after enrollment into the study)