Development of Novel MRI Methods for Detecting and Measuring Renal Injury/Fibrosis
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Kidney Diseases
- Sponsor
- Children's Hospital Medical Center, Cincinnati
- Enrollment
- 37
- Locations
- 1
- Primary Endpoint
- Development of noninvasive MRI methods to measure kidney disease using T1rho mapping.
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The investigators plan a prospective cross-sectional study of pediatric and adult healthy volunteers and patients with chronic kidney disease that will correlate a variety of quantitative MRI biomarkers with severity of renal insufficiency and available histopathology. Over 3 years, the investigators will recruit approximately 20 healthy volunteers, 20 patients with chronic kidney disease (CKD) Stage 2-5, and 20 patients with renal transplant kidneys. The investigators also plan to assess the effect of inflammation on the quantitative MRI biomarkers by recruiting approximately 20 additional patients with active lupus nephritis.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Subjects who meet all of the following criteria will be eligible for the study:
- •≥ 10 and ≤ 25 years of age and;
- •Kidney transplant patients, who have had a recent kidney biopsy (within 1 year) that shows interstitial fibrosis OR
- •Patients with CKD Stage 2-5 who have previously had a biopsy (within 1 year) OR
- •Lupus patients with active nephritis who will undergo biopsy evaluation before and after induction therapy OR
- •Healthy Controls
Exclusion Criteria
- •Subjects who meet any of the following criteria will be excluded from the study:
- •Known contraindication to MR imaging (e.g., implanted non-MRI compatible device)
- •Known or suspected pregnancy. Female subjects of child bearing potential will undergo a urine pregnancy test prior to imaging.
- •Inability to undergo MRI without sedation/anesthesia.
- •Non-English Speaking
Outcomes
Primary Outcomes
Development of noninvasive MRI methods to measure kidney disease using T1rho mapping.
Time Frame: 3 years
Development of noninvasive MRI methods to measure kidney disease using T2 mapping.
Time Frame: 3 years
Development of noninvasive MRI methods to measure kidney disease using magnetization transfer imaging.
Time Frame: 3 years
Development of noninvasive MRI methods to measure kidney disease using MR elastography.
Time Frame: 3 years
Development of noninvasive MRI methods to measure kidney disease using quantitative T1 mapping.
Time Frame: 3 years
Development of noninvasive MRI methods to measure kidney disease using diffusion-weighted imaging.
Time Frame: 3 years
Intra-voxel incoherent motion and diffusion tensor imagining will be measured.