A Clinical study to find the effect of melatonin in reducing stress to intubation in patients undergoing surgeries.
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2024/05/066842
- Lead Sponsor
- BGS Global Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patients willing to give written informed consent.
2. ASA physical status I,II.
3. Patients posted for elective surgery under general anaesthesia with endotracheal intubation.
Exclusion Criteria
1. Patients with anticipated difficult Intubation.
2. Patients with ASA physical status III and above.
3. Patients allergic to study drug.
4. Patients with steroids and antipsychotics.
5. Patients with history of active seizure disorders or active neurological disorders.
6. Patients with history of chronic alcoholism.
7. Patients with greater than 30kg per meter square.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To study the effect of preoperative sublingual melatonin 6mg on the pressor response by monitoring the hemodynamic changes to laryngoscopy and intubation.Timepoint: 1 hour before induction, immideately after intubation - 1min, 3min, 5min ,10 min and 15 minutes after intubation.
- Secondary Outcome Measures
Name Time Method To study the adverse effects of sublingual melatonin like dizziness and nausea.Timepoint: 2 hours