Relevance of the Peripheral Cholinesterase-activity on Neurocognitive Dysfunctions in Surgical Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 815
- 试验地点
- 9
- 主要终点
- Postoperative Delirium
研究概览
简要总结
In this prospective, multicenter observational study the investigators capture the perioperative course of peripheral cholinesterase activity. The focus is the perioperative inflammation causing postoperative delirium. Therefore we measure the activity of Acetylcholine-Esterase and Butyrylcholine-Esterase in whole blood of adults in the perioperative context. Early postoperative delirium will be detected by Nu-DESC in the Recovery Room or the Postanaesthesia-Care-Unit. The course of the peripheral cholinesterase activity will be compared with the incidence of postoperative delirium and other clinical dysfunctions.
We follow up the patients for up to five years regarding Delirum, comorbidities and mortality data.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male and female patients with age 18 years and above scheduled for surgery with planned stay in Recovery Room or Postanesthesia-Care-Unit
- •Offered patient information and written informed consent
- •In-hospital stay for at least 24 hours
排除标准
- •Patients with known pseudocholinesterase deficiency
- •Participation in prospective intervention studies during the study period
- •Analphabetism
- •Unability of German and English language use
- •Anacusis or Hypoacusis with hearing aid device, Amaurosis
- •Lacking willingness to save and hand out data within the study
- •Accommodation in an institution due to an official or judicial order
- •Coworker of the clinic (study center)
结局指标
主要结局
Postoperative Delirium
时间窗: Participants will be followed in the sample period, an exspected average of three days
Postoperative Delirium (measured by Nursing Delirium Screening Scale)
次要结局
- Organ Dysfunctions(Participants will be followed in the sample period, an exspected average of three days)
- Concomitant medication(Participants will be followed in the three postoperative days sample period)
- Postoperative Pain(Participants will be followed in the three postoperative days sample period)
- Duration of Intensive Care Unit Stay(Participants will be followed in the sample period, an exspected average of seven days)
- Duration of Mechanical Ventilation(Participants will be followed in the sample period, an exspected average of 168 hours)
- Readmission rate(Participants will be followed in the sample period, an exspected average of four weeks)
- Postoperative Mortality(Participants will be followed for the duration of the sample period an exspected average of five years)
- Duration of Hospital Stay(Participants will be followed in the sample period, an exspected average of four weeks)
- Hospital Treatment Data(Participations will be followed for the duration of the operation day, an exspected time average of eight hours)
- Postoperative Delirium(Participants will be followed in the sample period, an exspected average of five years)
- Comorbidities(Participants will be followed in the sample period, an exspected average of five years)
研究者
Claudia Spies
Department of Anesthesiology and Intensive Care Medicine CVK/CCM, Charite - Universitätsmedizin Berlin, Germany
Charite University, Berlin, Germany