Cerebrospinal Fluid Cholinergic Biomarkers and Postoperative Cognitive Change in Aged Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Necrosis of Femoral Head
- Sponsor
- RenJi Hospital
- Enrollment
- 102
- Locations
- 1
- Primary Endpoint
- Concentration of acetylcholinesterase in CSF
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Previous study demonstrated that the condition of central cholinergic nerve is important for the postoperative cognitive dysfunction. In present study investigators hypothesized that the acetylcholine concentration in the cerebral spinal fluid is associated to the postoperative cognitive changes in aged patients undergoing osteopathic surgery.
Investigators
diansan su
Principal Investigator
RenJi Hospital
Eligibility Criteria
Inclusion Criteria
- •Elder than 60 years old
- •Spoke proficient Mandarin Chinese
- •Agree to undergoing spinal plus general anesthesia
- •Selected total knee replacement surgery
Exclusion Criteria
- •Patients with neurological and/or psychiatric diseases, including AD, stroke and psychosis
- •Have contraindication for spinal anesthesia such as clotting disorder local infection in the puncture site
- •Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
- •Several audition or vision disorder
- •Unwillingness to comply with the protocol or procedures.
Outcomes
Primary Outcomes
Concentration of acetylcholinesterase in CSF
Time Frame: During spinal anesthesia
Concentration of Acetylcholine in CSF
Time Frame: During spinal anesthesia
Short-term postoperative cognitive dysfunction rate
Time Frame: The day before surgery and 7 days after surgery (or before leave hospital)
Concentration of choline acetyltransferase in CSF
Time Frame: During spinal anesthesia
Secondary Outcomes
- Long-term postoperative cognitive dysfunction rate(Two months after surgery)