Reproducibility of qualitative, semi quantitative and quantitative DCE- MR Imaging in the knee.

• Conditions: chronic inflammatory arthritis; rheumatoid arthritis; 10003816; 10013361

• Registration Number: NL-OMON30767
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

RA-patients: artritis of a knee joint
Healthy volunteers: none

Exclusion Criteria

RA-patients : claustrofobia, known allergy to gadolineum contrast agent
Healty volunteers: 1)history of joint disease 2)claustrofobia, known allergy to gadolineum contrast agent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>DCE-MRI scans obtained at the two time points will be scored according to the<br /><br>omeract RAMRIS score by DCE-MR color coded shape mapping and by compartmental<br /><br>analysis (quantitative analysis) (appendix B).<br /><br>Correlation between the two time points will be evaluated by the Spearman*s<br /><br>rank correlation coefficient. In addition the change in mean, within patient<br /><br>standard deviation, within patient coefficient of variation and the<br /><br>repeatability will be determined.<br /><br>Differences between healthy individuals and arthritis patients will be<br /><br>evaluated to determine the basal level of enhancement</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>