Skip to main content
MedPathMedPath Home
Clinical Trials/NCT02941016
NCT02941016
Withdrawn
Phase 4

Vascular Inflammation and Cholesterol Lowering Therapy

Rigshospitalet, Denmark1 site in 1 countryOctober 2016
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
ConditionsLipid Lowering, Vascular Inflammation
InterventionsEvolocumab or Alirocumab
DrugsEvolocumab or Alirocumab

Overview

Phase
Phase 4
Intervention
Evolocumab or Alirocumab
Conditions
Lipid Lowering, Vascular Inflammation
Sponsor
Rigshospitalet, Denmark
Locations
1
Primary Endpoint
Change in vascular inflammation
Status
Withdrawn
Last Updated
5 years ago
OverviewInvestigatorsEligibility CriteriaArms & InterventionsOutcomesSitesSimilar Trials

Overview

Brief Summary

This study aim to detect change in vascular inflammation following intense lipid lowering therapy

Registry
clinicaltrials.gov
Start Date
October 2016
End Date
October 1, 2020
Last Updated
5 years ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Rasmus S. Ripa

Staff Physician

Rigshospitalet, Denmark

Eligibility Criteria

Inclusion Criteria

  • •treatment with PCSK-9 inhibitors

Exclusion Criteria

  • •Infection Pregnancy Severe claustrophobia Weight \>140 kg

Arms & Interventions

Lipid lowering

Intervention: Evolocumab or Alirocumab

Outcomes

Primary Outcomes

Change in vascular inflammation

Time Frame: 12 weeks

Change in standard uptake value (SUV) of flourdeoxyglucose (FDG) before and after initiation of lipid lowering therapy

Study Sites (1)

Loading locations...

Similar Trials

Completed
Phase 4
Influence of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering TreatmentMyocardial Infarction [C14.907.585.500]
NCT01245894Odense University Hospital87
Completed
Phase 3
Lipid Research Clinics Coronary Primary Prevention Trial (CPPT)Cardiovascular DiseasesCoronary DiseaseHeart DiseasesMyocardial Ischemia
NCT00000488National Heart, Lung, and Blood Institute (NHLBI)
Completed
Phase 4
Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Endothelial FunctionEndothelial DysfunctionAtherosclerosis
NCT01223625Odense University Hospital87
Completed
Phase 4
Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima-media Thickness (CIMT)ST-segment Elevation Myocardial InfarctionSubclinical Carotid Atherosclerosis
NCT01203982Odense University Hospital87
Recruiting
Phase 4
Effect of Intensive LDL-cholesterol Targeting for Elderly Patients With Cardiovascular Disease: I-OLD TrialCardiovascular Disease
NCT05361421Yonsei University1,200