Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on the Coronary Microcirculation

Odense University Hospital1 site in 1 country87 target enrollmentNovember 2007

ConditionsMyocardial Infarction [C14.907.585.500]

InterventionsLow-dose Rosuvastatin High-dose Rosuvastatin

DrugsLow-dose Rosuvastatin High-dose Rosuvastatin

Overview

Phase: Phase 4
Intervention: Low-dose Rosuvastatin
Conditions: Myocardial Infarction [C14.907.585.500]
Sponsor: Odense University Hospital
Enrollment: 87
Locations: 1
Primary Endpoint: The primary endpoint was the change from baseline in Index of microcirculatory resistance(IMR).
Status: Completed
Last Updated: 15 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of this study was to measure the effect of low- and high-dose lipid-lowering treatment with rosuvastatin on the coronary physiology parameters.

Registry

clinicaltrials.gov

Start Date

November 2007

End Date

June 2010

Last Updated

15 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Odense University Hospital

Eligibility Criteria

Inclusion Criteria

•ST-segment elevation myocardial infarction
•no prior treatment with statins and
•a non significant lesion in one of the two non-culprit coronary arteries

Exclusion Criteria

•age below 18 or above 81 years,
•unconscious patients,
•serum creatinine \> 176μmol/L,
•hypothyroidism ((TSH \> 1.5 x ULN (upper limit of normal)),
•current liver disease (ALAT \> 2 x ULN),
•unexplained creatine kinase \> 3 x ULN,
•alcohol or drug abuse within the last five years,
•prior myopathy or serious hypersensitivity reaction caused by statins,
•women with childbearing potential who were not using chemical or mechanical contraception,
•pregnant or breastfeeding women,