Comparison of efficacy of Paclitaxel with Cisplatin when given weekly along with radiation in patients suffering from Head and Neck cancers.
Phase 2
Completed
- Registration Number
- CTRI/2017/09/009864
- Lead Sponsor
- Jawaharlal Institute of Post Graduate Medical Education and Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 54
Inclusion Criteria
1.all biopsy proven oral cavity, oropharyngeal
and hypopharyngeal cancer patients are taken
into trial
2.Normal liver function tests and normal
hemogram reports
3.normal renal function tests should be there
to include under the trial.
4 performance score according to ECOG scale
should be more than or equal to 2
Exclusion Criteria
1. patients with distant metastasis
2. patients with uncontrollable hypertension
and diabetes.
3. history of previous oncological surgery for
the same condition
4. history of previous irradiation to the same
site
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess loco regional control in patients of oral cavity, oro-pharyngeal and hypo pharyngeal cancers, treated with concurrent chemo radiation using weekly Paclitaxel or weekly Cisplatin. <br/ ><br> <br/ ><br>Timepoint: The outcome will be assessed three months after treatment. <br/ ><br> <br/ ><br>
- Secondary Outcome Measures
Name Time Method To assess acute toxicities in patients treated with CCRT using weekly Paclitaxeland weekly cisplatin in oral cavity, oropharyngeal and hypo pharyngeal cancers.Timepoint: Acute toxicities will be assessed through out the course of treatment and within three weeks after treatment.