Acute Effects of Fats on Satiety and Energy Needs

Not Applicable

Completed

• Conditions: Obesity
• Interventions: Other: MUFA; Other: PUFA-LA; Other: SFA; Other: ALA; Other: LCn3

• Registration Number: NCT02496936
• Lead Sponsor: USDA Grand Forks Human Nutrition Research Center

Brief Summary

The purpose of this study is to assess the acute effect of dietary fat on satiety and energy metabolism.

Detailed Description

The influences of specific dietary fat sources on satiety, appetite and energy utilization remains unclear; evidence is lacking on whether responses vary according to acute intake. The researchers will use a controlled setting to determine whether the source of dietary fat is related to perceived satiety, satiety hormone responses, and energy expenditure by conducting experiments to evaluate short term (acute) effects.

Study Timeline

• Study First Submitted: 2015-07-07
• Study First Submitted QC: 2015-07-10
• Study First Posted: 2015-07-14
• Study Start: 2015-12
• Primary Completion: 2019-10-30
• Study Completion: 2019-10-30
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-01
• Last Update Posted: 2022-08-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 23

Inclusion Criteria

• body mass index between 18.0-34.9 kg/m2
• free of major diagnosed, untreated medical conditions
• controlled hypertension
• non-smoking or use of other tobacco products, including e-cigarettes
• not taking steroid-based medications
• not planning to or currently attempting to gain or lose weight
• willing to comply with study demands
• use of oral contraceptives
• low intake of long chain omega 3 fatty acids

Exclusion Criteria

• diagnosed eating disorders
• diabetes (blood sugar ≥ 126 mg/dl)
• hypertension (systolic ≥ 160 mmHg or diastolic > 100 mmHg)
• diagnosed cardiovascular, pulmonary, skeletal and metabolic disease
• currently pregnant or planning to become pregnant, or lactating
• taking medications known to affect appetite, blood lipids, body composition, body weight, or food intake (appetite control drugs, steroids, antidepressants)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Monounsaturated Fat (MUFA)	MUFA	30 grams monounsaturated fat in the form of high oleic canola oil will be provided to subject in a smoothie drink
Polyunsaturated Fat Linoleic (PUFA-LA)	PUFA-LA	30 grams polyunsaturated fat in the form of high linoleic sunflower oil will be provided to subject in a smoothie drink
Saturated Fat (SFA)	SFA	30 grams saturated fat in the form of heavy whipping cream will be provided to subject in a smoothie drink
Polyunsaturated Fat Alpha-Linolenic (ALA)	ALA	30 grams polyunsaturated fat in the form of flaxseed oil will be provided to subject in a smoothie drink
Polyunsaturated Fat Long Chain Omega-3 (LCn3)	LCn3	30 grams polyunsaturated fat in the form of fish oil (Coromega Omega3 Squeeze) will be provided to subject in a smoothie drink

Primary Outcome Measures

Name	Time	Method
Acute effect of fat intake on energy expenditure as determined by metabolic rate	Incremental Area Under the Curve (iAUC) of metabolic rate from 0 to 4 hours

Trial Locations

Locations (1)

USDA Grand Forks Human Nutrition Research Center; 🇺🇸 Grand Forks, North Dakota, United States