Hunger, Satiety, and Metabolic Responses to High-fat Meals of Varying Fatty Acid Composition

Not Applicable

• Conditions: Body Weight Changes
• Interventions: Other: SFA-rich HF Meal; Other: MUFA-rich HF Meal; Other: PUFA-rich HF Meal

• Registration Number: NCT02966444
• Lead Sponsor: Texas Christian University

Brief Summary

This study evaluates the effects of dietary fatty acid composition from high fat meals on markers of hunger, satiety and metabolism.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-10
• Study First Submitted: 2016-11-08
• Study First Submitted QC: 2016-11-15
• Study First Posted: 2016-11-17
• Status Verified: 2018-07
• Primary Completion: 2018-07
• Study Completion: 2018-07
• Last Update Submitted: 2018-07-24
• Last Update Posted: 2018-07-26

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 16

Inclusion Criteria

• BMI of >18.5-24.9kg/m2
• Woman
• 18-40yrs of age

Exclusion Criteria

• Evidence of weight loss or gain exceeding 5% of their body weight within the past 3 months.
• Plans to lose weight or begin a weight loss program between initiation of study and final testing.
• Plans to begin an exercise program or change current exercise routines between initiation of study and final testing.
• Is on a medically prescribed diet
• Does not consume breakfast regularly
• Rate less than 80% of foods offered in the buffet at 50mm or more on the 100mm VAS as palatable
• Medications that could influence appetite or sensory function
• Reports of metabolic or endocrine disease, gastrointestinal disorders, or history of medical or surgical events that could affect fat digestion and hormone signaling.
• Any chronic disease including type II diabetes, hypothyroidism, hyperthyroidism, cardiovascular disease, and cancer
• Any supplements that a subject begins taking between initiation of study and final testing.
• Anyone who is currently pregnant, lactating, or planning on becoming pregnant before the conclusion of this study.
• Anyone who has allergies to any of the components of the liquid meals
• Anyone who has donated blood in the last 20 days

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
SFA-rich HF Meal	SFA-rich HF Meal	High-fat meal rich in saturated fatty acids
MUFA-rich HF Meal	MUFA-rich HF Meal	High-fat meal rich in monounsaturated fatty acids
PUFA-rich HF Meal	PUFA-rich HF Meal	High-fat meal rich in polyunsaturated fatty acids

Primary Outcome Measures

Name	Time	Method
Peptide-YY	18 months

Secondary Outcome Measures

Name	Time	Method
Visual Analog Scale	18 months

Trial Locations

Locations (1)

Texas Christian University; 🇺🇸 Fort Worth, Texas, United States