Sleep and circadian rhythm disruption in patients undergoing laparoscopic donor nephrectomy

Not Applicable

• Conditions: Disturbance in the circadian clock post kidney donation surgery.; Sleep disturbance post kidney donation surgery.; Surgery - Other surgery; Other - Conditions of unknown or disputed aetiology (such as chronic fatigue syndrome/myalgic encephalomyelitis)

• Registration Number: ACTRN12611001194954
• Lead Sponsor: Dr Andrew Kennedy-Smith

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-11-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Patients must:

be scheduled for laparoscopic donor nephrectomy surgery at Wellington Hospital.

provide written informed consent.

Exclusion Criteria

Patients will be excluded if:
they do not meet the inclusion criteria.
they are already enrolled in another concurrent clinical trial.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To investigate the effects of hospitalisation, anaesthesia and surgery resulting in significant post-operative sleep and circadian disruption in otherwise healthy fit kidney donor patients. These effects will be investigated via actigraphic monitoring of sleep wake cycles and light levels and 6-sulphatoxymelatonin (aMT6s), a marker of the circadian clock, will be assayed in urine samples.[At baseline (pre-operatively at home), on first post-operative day (in hospital) and 4 and 12 week follow ups (post-operatively at home).]

Secondary Outcome Measures

Name	Time	Method
To investigate the extent of mood reduction and fatigue in these patients correlates with the extent of post-operative sleep and circadian disruption. Patients will be asked to keep sleep diaries, pain assessment visual analogue scales and questionnaires on sleeping habits (Munich Chronotype Questionnaire and Horne-Ostberg Questionnaire) and a mood questionnaire (Beck Depression Scales).[At baseline (pre-operatively at home), on first post-operative day (in hospital) and 4 and 12 week follow ups (post-operatively at home).]