Microalbuminuria Predicting CIAKI After CAG

• Conditions: Contrast-induced Acute Kidney Injury; Microalbuminuria
• Interventions: Other: microalbuminuria

• Registration Number: NCT02808845
• Lead Sponsor: The First Affiliated Hospital with Nanjing Medical University

Brief Summary

The purpose of this study is to investigate the association between pre-existing microalbuminuria and contrast-induced acute kidney injury (CIAKI) following coronary angiography (CAG).

Detailed Description

Not available

Study Timeline

• Status Verified: 2016-06
• Study First Submitted: 2016-06-13
• Study First Submitted QC: 2016-06-21
• Last Update Submitted: 2016-06-21
• Study First Posted: 2016-06-22
• Last Update Posted: 2016-06-22
• Study Start: 2016-12
• Primary Completion: 2020-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 800

Inclusion Criteria

• Patients with eGFR≥30ml/min and without macroalbuminuria undergoing CAG.

Exclusion Criteria

• Pregnancy
• Lactation
• Allergic history of contrast media
• Having been received contrast media within 7 days
• Use of nephrotoxic medications within 7 days
• eGFR <30 ml/min, macroalbuminuria (ACR >300 mg/g)
• Renal transplantation, emergent coronary angiography
• Cardiogenic shock, pulmonary edema
• Use of intra-aortic balloon pump (IABP) or mechanical ventilation
• Multiple myeloma and other malignant tumor
• Life expectancy less than 12 months

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
microalbuminuria with eGFR≥60ml/min	microalbuminuria	microalbuminuria group with estimated glomerular filtration rate (eGFR) ≥60ml/min.
microalbuminuria group with eGFR<60ml/min	microalbuminuria	microalbuminuria group with estimated glomerular filtration rate (eGFR) \<60ml/min.

Primary Outcome Measures

Name	Time	Method
number of participants with increase in SCr of at least 44.2 umol/L higher than before	24-48 hours after CAG	number of participants with the difference of SCr before and after CAG over 44.2 umol/L.
number of participants with increase of SCr over 25% higher than before	24-48 hours after CAG	number of participants with an increase of SCr over 25% higher than before.
changes of serum creatinine (SCr, umol/L)	24-48 hours after CAG	the difference of SCr before and after CAG.

Secondary Outcome Measures

Name	Time	Method
changes of urine albumin to creatinine ratio (ACR, mg/g)	24-48 hours after CAG	the difference of ACR before and after CAG

Trial Locations

Locations (1)

First Affiliated Hospital of Nanjing Medical University; 🇨🇳 Nanjing, Jiangsu, China