Prospective study for patients with cerebral vessel disease in Tokyo Women's Medical Univeristy
Not Applicable
- Conditions
- Cerebrovascular Disease
- Registration Number
- JPRN-UMIN000026671
- Lead Sponsor
- Tokyo Women's Medical Univeristy
- Brief Summary
Both total and modified Small nessel disease score : SVD scores were significantly associated with MMSE and MoCA-J scores. After adjustment for age, sex, education, risk factors, and medial temporal atrophy, the association between the modified SVD score and global cognitive scores remained significant. The modified SVD score was independently associated with attention.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 1005
Inclusion Criteria
Not provided
Exclusion Criteria
1. A history of neurodegenerative disease, neuroimmunology disease, neuroinfection 2. Alcohol toxication, Drug toxication 3. Dementia 4. Other any reasons judged from principle investigator
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Stroke, Vascular events, death, dementia, Parkinsonism, ADL, urinary incontinence, aspiration peumonia, depression (every 3 year up to 6 year)
- Secondary Outcome Measures
Name Time Method Brain MRI, carotid ultrasound, cognitive function, gait function, motor function (UPDRS Part III), apathy scale, SDS depression scale, urinary function (measurement of liquid in the bladder), motor and sensory evoked potential, flow-mediated vasodilation, transcranial doppler for cerebrovascular reserve (every 3 year up to six year)