Cerebral Vascular Reserve in Small Vessel Disease and Alzheimers Disease
- Conditions
- Dementia, VascularAlzheimer Disease
- Interventions
- Diagnostic Test: Cerebral [15O]H2O PET before and after diamox infusion
- Registration Number
- NCT05443308
- Lead Sponsor
- Bispebjerg Hospital
- Brief Summary
Alzheimers disease and cerebral small vessel disease have a considerably overlap in patients and have common risk factors. The diseases are difficult to separate in individual patients and we hypothesize that a reduced cerebral vascular reserve may be a measurement of small vessel disease independent of Alzheimers disease.
Patients with presumed Alzheimers disease (n=20), cerebral small vessel disease (n=20) and healthy age-matched subjects (n=15) are examined with quantitative \[15O\]H2O positron emission tomography (PET) for measurements of brain perfusion before and after diamox infusion that dilates cerebral vessels. Additional \[15O\]H2O PET scans of the heart allows for a non-invasive input function so the cerebral vascular reserve can be measured quantitatively.
- Detailed Description
Alzheimers disease and cerebral small vessel disease are increasingly common in the elderly population and constitute around 90% of new dementia cases in Denmark. The diseases have a considerably overlap in patients and have common risk factors. The cause of dementia can be difficult to separate in individual patients but a reduced cerebral vascular reserve may be a measurement of small vessel disease independent of Alzheimers disease. We hypothesized that patient with small vessel disease have reduced increase in brain perfusion after medical brain vessel dilatation. While Alzheimer patients may have reduced perfusion in rest but normal increase after medical brain vessel dilatation as compared to healthy subjects.
Patients with presumed Alzheimers disease (n=20), cerebral small vessel disease (n=20) and healthy age-matched subjects (n=15) are examined with quantitative \[15O\]H2O PET for measurements of brain perfusion before and after diamox infusion that dilates cerebral vessels. Additional \[15O\]H2O PET scans of the heart allows for a non-invasive input function so the cerebral vascular reserve can be measured quantitatively.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- presumed Alzheimer's Disease (group 1)
- diagnosed with small vessel disease of the brain by MRI and presumed cognitive dysfunction (group 2)
- major claustrophobia
- major psychiatric diseases
- other major somatic diseases
- allergy to diamox
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Small vessel disease Cerebral [15O]H2O PET before and after diamox infusion patients diagnosed with small vessel disease of the brain by MRI and presumed cognitive dysfunction and no other known psychiatric or other major diseases. age \> 60 years Healthy subjects Cerebral [15O]H2O PET before and after diamox infusion Age-matched subjects with no known vascular, psychiatric or other major diseases. age \> 60 years Alzheimer Disease Cerebral [15O]H2O PET before and after diamox infusion patients with presumed Alzheimer disease and no known vascular, psychiatric or other major diseases age \> 60 years
- Primary Outcome Measures
Name Time Method Vascular reserve perfusion 20 min after diamox infusion Brain perfusion after diamox infusion (mL / min / 100 g tissue)
Vascular reserve change 20 min after diamox infusion Change in Brain perfusion after diamox infusion (mL / min / 100 g tissue and %) compared to before diamox infusion
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Bispebjerg
🇩🇰Copenhagen, Copenhagen NV, Denmark