Cerebrovascular dysfunction in Alzheimer and mild cognitive impairment.

Completed

• Conditions: cerebrovasculaire dysfunctie; dementia; 10029305; alzheimer; mild cognitive impairment; 10047066

• Registration Number: NL-OMON30568
• Lead Sponsor: Academisch Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Alzheimer patients
Alzheimer diagnosed according to the DSM-IV criteria for dementia (American Psychiatric Association, 1994), and NINCDS-ADRDA criteria (McKhann et al., 1984)(probable, possible).
Presence of a reliable informant, who has contact with the patient at least once a week.
Informed consent of the patient before participation into the study.;MCI patients
The descriptions proposed by Petersen et al. (1999) are used to classify MCI.
Informed consent of the patient before participation into the study.;Controls
Informed consent before participation into the study.
Control matching parameters will be age, sex and level of education.

Exclusion Criteria

Alzheimer patients
If living in a nursing home at the start of the study.
Patients without a reliable informant.
Diagnosis of Vascular Dementia, according to NINDS/AIREN criteria (Roman et al., 1993)
Presence of micro-vascular pathology as defined by the Fazekas scale (Fazekas, 1987)
Use of psychopharmacological medication.
Abuse of alcohol and/or drugs.
Diabetes
Heart disease
Presence of hypertension will be considered as a co-variate in the analysis.;To exclude patients with a possible stenosis (> 50%) of extra- and/or intracranial vessels a non-invasive and non-aggravating standard duplex investigation will be performed in all subjects. Patients without a temporal *doppler* window will be excluded. In general about 1 out of 10 subjects will have no temporal window. According to this about 22 Alzheimer patients will have to be screened to acquire a group of 20 subjects.;MCI patients
If living in a nursing home at the start of the study.
Use of psychopharmacological medication.
Abuse of alcohol and/or drugs.
Diabetes
Heart disease
Presence of hypertension will be considered as a co-variate.;To exclude patients with a possible stenosis (> 50%) of extra- and/or intracranial vessels a non-invasive and non-aggravating standard duplex investigation will be performed in all subjects.
Patients without a temporal *doppler* window will be excluded. In general about 1 out of 10 subjects will have no temporal window. According to this about 22 MCI patients will have to be screened to acquire a group of 20 subjects.

Controls
Use of psychopharmacological medication.
Abuse of alcohol and/or drugs.
Diabetes
Heart disease;To exclude participants with a possible stenosis (> 50%) of extra- and/or intracranial vessels a non-invasive and non-aggravating standard duplex investigation will be performed in all subjects.
Participants without a temporal *doppler* window will be excluded. In general about 1 out of 10 subjects will have no temporal window. According to this about 22 controls will have to be screened to acquire a group of 20 subjects
Control matching parameters will be age, sex and level of education.
Presence of hypertension will be considered as a co-variate.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified