Cerebral amyloid angiopathy and clinical phenotype of Alzheimer's disease: a prospective multimodality imaging study

Recruiting

• Conditions: I68.0; F00; Dementia in Alzheimer disease; Cerebral amyloid angiopathy

• Registration Number: DRKS00030633
• Lead Sponsor: Klinik für Neurologie Uniklinik RWTH Aachen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-03-21
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Written declaration of consent from the study participant in the case of capacity to consent

Exclusion Criteria

- Contraindication for MRI examination
- Other causes of intracranial haemorrhage or cortical haemosiderosis other than CAA (e.g. acquired or hereditary coagulation or platelet aggregation disorders, intracranial vascular malformations, CNS vasculitis, significant traumatic brain injury).
- Hereditary AD or hereditary CAA
- Severity of cognitive impairment according to the Global Deterioration Scale >= 5 (GDS; GDS 5 = moderate dementia)
- Atypical phenotypic presentation of AD, such as logopenic primary progressive aphasia or posterior cortical atrophy (PCA)

Study & Design

• Study Type: observational
• Study Design: Not specified