Amyloid pathology and vascular disease in focus: exploring interaction in two pathways towards neurodegeneratio

• Conditions: neurodegeneratieve aandoeningen; Dementia; vascular pathology; 10042258

• Registration Number: NL-OMON46142
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 700

Inclusion Criteria

- persons are eligible who are non-demented;
- who had at least one previous complete brain MRI examination and assessment of vascular pathology within The Rotterdam Study;
- and who are scheduled for a regular follow-up visit which will include repeat MRI and cognitive testing.

Exclusion Criteria

- Contraindications for PET/CT imaging:
· hypersensitivity to the active substance (ascorbic acid or ethanol anhydrous)
· extreme claustrophobia
· inability to lie flat
· pregnancy or breastfeeding (not likely in our population).

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>How (progression of) systemic vascular pathology and vascular brain pathology<br /><br>relate to amyloid-* pathology; how amyloid-* and vascular pathologies interact<br /><br>in their association with cognitive function and decline over time.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N/A</p><br>