The Follow-up in sporadic Cerebral Amyloid Angiopathy Study

Recruiting

• Conditions: CAA; sCAA; sporadic cerebral amyloid angiopathy; 10007963

• Registration Number: NL-OMON52554
• Lead Sponsor: eurologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 190

Inclusion Criteria

1. Age >= 50y
2. Ability and willingness to provide written informed consent
3. Probable CAA based on the Boston criteria 2.0, and no family history of
HCHWA-D, including CAA related inflammation

Healthy controls: age- and sex matched to the sCAA group, no history of
neurological disease and free of substantial memory complaints

Exclusion Criteria

1. Contra-indications for 3T/7T MRI as determined by the 7Tesla safety
committee (exclusion for a subpart of the study).
2. Contraindications for lumbar puncture (exclusion for a subpart of the
study).

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main parameters are microvascular CAA markers on 3T-MRI and 7T-MRI, changes<br /><br>in CSF, recurrence ICH rate and clinical outcome.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Other studyparameters will include: date of birth, gender, medical history,<br /><br>consumption of alcohol/caffeïne/drugs, smoking, medication use, cardiovascular<br /><br>risk factors, neurological history, BMI, blood pressure and APOE genotype.</p><br>