Impact of targeted blood pressure management versus standard care amongst patients undergoing major abdominal surgeries
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Any organ dysfunction 24 hours postoperatively
研究概览
简要总结
We aim to evaluate the impact of a targeted blood pressure management within 20 % of baseline value amongst high risk patients undergoing major abdominal surgery. The impact is to be assessed by looking for evidences of any organ dysfunction, cardiac, renal, respiratory, coagulopathy or neurological outcomes.
This may provide us insights on the benefits ofa targeted blood pressure management amongst high risk patients undergoig abdominal surgery
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 45.00 Year(s) 至 72.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA II and above patients above 45 years with one of the following
- •Coronary artery disease
- •cerebrovascular accident
- •peripheral vascular disease undergoing major abdominal surgery lasting more than 4 hours.
排除标准
- •1.emergency surgery 2.Preoperative ventilation or COPD 3.Renal dysfunction creatinine more than 1.5 4.CAD EF less than 35% 5.AST ALT more than twice normal.
结局指标
主要结局
Any organ dysfunction 24 hours postoperatively
时间窗: 24 hours postoperatively in the ICU
1 Renal as per RIFLE criteria
时间窗: 24 hours postoperatively in the ICU
2 Elevated hsTropT
时间窗: 24 hours postoperatively in the ICU
3 Respiratory SpO2 less than 94 or need for respiratory assist devices
时间窗: 24 hours postoperatively in the ICU
4 Neurological GCS less than 14
时间窗: 24 hours postoperatively in the ICU
5 Coagulation Platelet INR as per SOFA
时间窗: 24 hours postoperatively in the ICU
次要结局
- Length of ICU stay(Length of hospital stay)
研究者
DrLakshmi Kumar
Amrita Institute of Medical Sciences