Postoperative Painful Chronicization After Knee Replacement Surgery : Exploratory Study of BDNF's Kinetics
- Conditions
- Total Knee ArthroplastyChronic Postoperative Pain
- Interventions
- Diagnostic Test: blood test
- Registration Number
- NCT04604847
- Lead Sponsor
- University Hospital, Montpellier
- Brief Summary
Chronic pain is an extremely disabling disease. It is a major public health problem due to the lack of effective therapy.
Chronic postoperative pain (CPOP) is defined by a painful symptomatology in the operated area unrelated to previous pain, present for more than 3 months, and without any link to surgical complication.
The prevalence of chronicization of postoperative pain is 30% after total knee arthroplasty.
Identification of clinical, biological and psychological profiles are crucial to prevent CPOP.
A biologic factor, Brain Derived Neurotrophic Factor (BDNF) produced by a variety of cells is a key regulator of neuroplasticity. BDNF is increasingly studied in the mechanisms of cerebral sensitization and pain chronicization. The role of BDNF in pain of patients remains to be explored in a prospective study. The aim of this observational study is to compare the kinetics of BDNF after total knee arthroplasty in patients with and without CPOP.
Patients will be included in the study at the preanesthetic consultation. Serum BDNF levels will be measured preoperatively, 48h postoperatively, 3 and 6 months after surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
- Social security affiliation
- Adult patients
- Signed informed consent
- Score ASA (American Society of Anesthesiology) 1-3
- Total knee arthroplasty
- Patient unable to exercise consent
- Pregnant women
- Vulnerable people
- Patients not included in the postoperative rehabilitation program
- Patients unable to complete the pain assessment questionnaires
- Chronic pain patients (other than knee arthrosis)
- Neuropathic pain patients (beforehand)
- Inflammatory diseases, progressive cancer, sepsis, immunosuppression known
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Total knee arthroplasty blood test patient operated for a total knee arthroplasty
- Primary Outcome Measures
Name Time Method BDNF level preoperative to 6 months after surgery assessed by ELISA technique
- Secondary Outcome Measures
Name Time Method Anxiety and Depression preoperative to 6 months after surgery evaluated by the Hospital Anxiety and Depression scale (HAD)
Pain level preoperative to 6 months after surgery evaluated by Visual Analog Scale (VAS)
Neuropathic pain diagnostic preoperative to 6 months after surgery evaluated by neuropathic pain diagnostic questionnaire (DN4)
Postoperative rehabilitation preoperative to 6 months after surgery evaluated by the Brief Pain Questionary (BPI)
Health related quality of life preoperative to 6 months after surgery evaluated by the SF-12 Health Survey
Pain level perception preoperative to 6 months after surgery evaluated by the The pain Catastrophizing Scale
Assessment of functional capacities in knee arthritis preoperative to 6 months after surgery evaluated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC)
Oxidative stress marker preoperative to 6 months after surgery 8-iso-prostaglandin F2α level by biochemical labeling
Trial Locations
- Locations (1)
Department of Anesthesiology and critical care, Lapeyronie University Hospital
🇫🇷Montpellier, France