Treatment of Postoperative Pain After Total Knee Arthroplasy Using Intravenous Lidocaine Infusion

Not Applicable

Withdrawn

• Conditions: Total Knee Arthroplasty
• Interventions: Drug: Lidocaine; Other: Preservative free normal saline; Procedure: Continuous femoral catheter block

• Registration Number: NCT00616850
• Lead Sponsor: Loma Linda University

Brief Summary

Total knee replacement is often associated with severe postoperative pain, especially in the first 24 hours. Patient controlled analgesia (PCA) and continuous femoral block with PCA are commonly used to treat postoperative pain after total knee arthroplasty. However, PCAs use opioids. Opioids are excellent painkillers but their use is hampered by side effects such as nausea, vomiting, bowel dysfunction, urinary retention, pruritus, sedation and respiratory depression. We propose to test the hypothesis that adding a low dose lidocaine infusion to PCAs will lower the amount of opioids that these patients receive, thereby improving patient safety while still providing adequate analgesia. In addition, continuous femoral block has been shown to provide superior postoperative pain control when compared to morphine PCA. Therefore, postoperative pain levels of study subjects will be compared to those subjects who receive a combination of a continuous femoral block catheter with a PCA.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-10
• Study First Submitted: 2008-02-04
• Study First Submitted QC: 2008-02-04
• Study First Posted: 2008-02-15
• Primary Completion: 2008-07
• Study Completion: 2009-07
• Status Verified: 2014-05
• Last Update Submitted: 2014-05-20
• Last Update Posted: 2014-05-22

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Undergoing a total knee arthroplasty
2. Be American Society of Anesthesiologist physical status 1,2, or 3
3. Be willing and capable of providing informed consent
4. Be English speaking

Exclusion Criteria

1. Age greater than 80 years old or younger than 18 years old
2. Congestive hear failure
3. Hepatic insufficiency
4. Neurological disorders
5. Psychiatric disorders
6. Steroid treatment
7. History of atrial fibrillation
8. Chronic pain disorder with opioid treatment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Group B	Lidocaine	Group B subjects will receive a low dose lidocaine (1.33 mg/kg/hr) infusion and a Patient Controlled Analgesia.
Group C	Preservative free normal saline	Group C subjects will receive placebo (preservative free normal saline) infusion and a Patient Controlled Analgesia.
Group A	Continuous femoral catheter block	Group A subjects will receive a continuous femoral block catheter and a Patient Controlled Analgesia (PCA).

Primary Outcome Measures

Name	Time	Method
Total PCA opioid consumption	72 hours

Secondary Outcome Measures

Name	Time	Method
Time to first flatus	72 hours postoperatively

Trial Locations

Locations (1)

Loma Linda University Medical Center; 🇺🇸 Loma Linda, California, United States