Postoperative pain relief for primary total knee arthroplasty: A randomised clinical trial of local infiltration anaesthesia followed by intraaticulary infusion compared to epidural infusion - Intraarticulary infiltration and infusio

Conditions: Patients with Osteoarthrosis undergoing elective total knee arthroplasty (TKA)

Registration Number: EUCTR2006-004638-33-DK

Lead Sponsor: Department of Orthopedic Surgery, Aarhus University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

Age>18 years
Primary total knee arthroplasty
Written informed consent
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

Known allergi or intolerance to one of the study drugs
Pregnat women
Pathological obesity (BMI>35)
Regular Narcotic use.
Patients in treatment for; Depression, epilepsy, diabetes, antacida.
Patient with Rheumatoid arthritis.
Contraindikations to spinal or epidural anaesthesia
Patient wich can not read and understand danish

Study & Design

Study Type: Interventional clinical trial of medicinal product

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: To determine wether local infiltrationanaestesia with Naropin added Toradol and Adrenaline combind with intraarticulary infusion of Naropin and Toradol after total knee arthroplasty can enchange analgesia compared with epidural infusion of Naropin and intravenous infusion of Toradol.;Secondary Objective: To investigate: <br>the occurrence of local and systemic adverse events.<br>Length of stay<br>the occurrence of postoperative Complications.<br>The inflammatoriske respons after TKA<br>Mobilisation level;Primary end point(s): Pain assement: Visuel analog Scale (VAS) (0-72 h postoperatively)<br>Morphine consumption (0-24-48 hours postoperatively)

Secondary Outcome Measures