Postoperative analgesia for Total knee replacement: A comparision between intrathecal morphine and peripheral nerve block.

• Conditions: Postoperative analgesia for Total Knee Replacement; MedDRA version: 14.0Level: HLGTClassification code 10007521Term: Cardiac arrhythmiasSystem Organ Class: 10007541 - Cardiac disorders; MedDRA version: 14.0Level: LLTClassification code 10029177Term: Nerve damageSystem Organ Class: 10022117 - Injury, poisoning and procedural complications; MedDRA version: 14.0Level: LLTClassification code 10010914Term: ConvulsionsSystem Organ Class: 10029205 - Nervous system disorders; MedDRA version: 14.0Level: PTClassification code 10038678Term: Respiratory depressionSystem Organ Class: 10038738 - Respiratory, thoracic and mediastinal disorders

• Registration Number: EUCTR2006-005802-29-GB
• Lead Sponsor: Gwent Healthcare NHS Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-06-27
• Last Update Posted: 19 March 2012

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Adult patients of ASA physical status I to III undergoing elective primary unilateral Total Knee Replacement surgery.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

The exclusion criteria include patients who refuse consent, revision surgery,history of adverse reaction or a contraindication to the administration of morphine, local anaesthetics,non steriodal anti-inflammatory drugs,paracetamol, tramadol, centrineuraxial block and peripheral nerve blocks.Pateints with history of chronic pain other than at the site of joint replacement and on strong regular opiods.Renal impairment , liver impairment, ASA physical status greater than III and weight below 60 kgs.

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified