*Local analgesia in total knee replacement: The effect of local analgesia shots on ropivacaine levels in shed blood collected with a retransfusion device and in patients plasma.*
Completed
- Conditions
- joint wear (osteoarthritis)own blood donation (autologous blood transfusion)10023213
- Registration Number
- NL-OMON34159
- Lead Sponsor
- Medisch Centrum Haaglanden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
- primary TKP
- Haemoglobin level above 7.5 mmol/L
- both arms can be used for blood collection
Exclusion Criteria
- allergic for used medication or other local anaesthetics
- major operation within 12 weeks before TKP surgery
- high risk patients for insultus epilepticus
- dutch language not mastered
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Ropivacaine will be quantified in patient serum (0, 1, 3, 6, 7 and 18-24 h<br /><br>after surgery) and in the shed blood collected with the Bellovac ABT system at<br /><br>the same time points postoperative. </p><br>
- Secondary Outcome Measures
Name Time Method <p>- VAS pain scores measured per protocol<br /><br>- Opioid consumption (amount of morfine used with PCA pump) 24, 48 and 72hrs<br /><br>- Several important time points will be documented; start operation, injection<br /><br>of single shot, tourniquet release, leaving recovery and blood samples </p><br>