Effect of Remimazolam Besylate versus Propofol on Haemodynamic Profiles in Patients Undergoing Thyroid Surgery with Recurrent Laryngeal Nerve Monitoring
- Conditions
- Thyroid nodule
- Registration Number
- ChiCTR2300076583
- Lead Sponsor
- Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
- Aged 18- 65 years, American Society of Anaesthesiologists (ASA) physical status classification I-III. <br>2. Patients undergoing thyroid surgery require IONM.<br>3. Expected duration of surgery to be 4 hours or less.<br>4. Body mass index (BMI) >= 18 kg/m2 and <= 30 kg/m2.<br>5. Participation in the study is voluntary and requires signed informed consent.
1.Participated in other clinical trials within the past 3 months. <br>2.Patients undergoing other surgery at the same time, emergency surgery, and subsequent admission to intensive care for post-operative care. <br>3.Patients with suspected allergy to remimazolam, propofol or any of the drugs used in this study (e.g. sufentanil, rocuronium, remifentanil, ciprofol, etc.). <br>4.Severe systemic cardiovascular disease, such as congestive heart failure, frequent premature ventricular contractions, uncontrolled hypertension/hypotension, etc. <br>5.Severe respiratory disease. <br>6.History of dementia, mental illness, or other central nervous system disorders, and current use of sedatives, or antidepressants.<br>7.End-stage liver failure or kidney disease requiring dialysis. <br>8.Researcher does not believe it is appropriate to participate in this clinical trial.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the occurrence of hypotension, defined as MAP= 30% below preoperative baseline, from induction of anesthesia to full recovery.;
- Secondary Outcome Measures
Name Time Method the administration of vasoactive agents; the number of hypotension or hypertension episodes requiring intervention;the cumulative duration of hypotension or hypertension;the dose of intraoperative rescue sedation and analgesia;the duration of extubation and awakening;the incidence of adverse events;