A study on the effect of magnesium sulphate in addition to fentanyl in craniotomy
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2022/11/047408
- Lead Sponsor
- Sir Ganga Ram Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
BMI - 18.5 - 27.5 kg/m2
ASA Grade - 1 & 2
Exclusion Criteria
1. Inability to obtain informed consent
2. Patient scheduled for emergency surgery
3. Pregnancy
4. Morbid obesity
5. Severe cardiac dysfunction
6. History of hypersensitivity of local or systemic anesthetic agents
7. Patients receiving beta-blockers or calcium channel blockers
8. Pacemaker in-situ
9. Deranged hepatic function
10. Deranged renal function
11. Deranged endocrine function
12. Known allergy to magnesium sulphate
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome of this study is to measure the <br/ ><br>difference in HR and SBP at prespecified time points in patients receiving IV <br/ ><br>magnesium sulphate with fentanyl versus IV fentanyl alone. <br/ ><br>Timepoint: Specified time points will be as follows: <br/ ><br>i. T0 - At the time of skull pin insertion <br/ ><br>ii. T1, T3, T5, T7, T10, T15 â?? At 01, 03, 05, 07, 10 and 15 minutes after skull pin <br/ ><br>insertion respectively.
- Secondary Outcome Measures
Name Time Method Measure the requirement of rescue medication (IV lignocaine 1.5 mg/kg) in patients showing 20% increase in HR and SBP at 01 and 03 minutesTimepoint: 1 minute (T1) after skull pin insertion <br/ ><br>3 minute (T3) after skull pin insertion