Efficacy and safety of peroperative oral/exogenous indomethacin for pain prognosis in patients undergoing knee arthroplasty
- Conditions
- Knee osteoarthritis
- Registration Number
- ITMCTR1900002666
- Lead Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
1. Preoperative diagnosis of simple knee osteoarthritis;
2. Aged between 40-75 years;
3. Regular review as required, with good compliance and ability to cooperate with the research of the subject.
1. With abnormal physical deformity, ligament injury around the knee joint, abnormal muscle strength and other abnormal physical factors;
2. Combined with tumor or systemic metabolic disease;
3. Long-term use of hormones;
4. Non-steroidal drugs were used 1 week before surgery;
5. Other treatments were used during treatment;
6. Suspected of a systemic or local infection;
7. The condition is critical and may be exacerbated by the inclusion of observations;
8. Those who are allergic to non-steroidal anti-inflammatory drugs;
9. All patients at risk of bleeding, eg. previous gastrointestinal bleeding or peptic ulcer.
10. Cannot make an accurate assessment of the effectiveness and safety of the drug;
11. Patients with diabetes or patients with skin lesions or skin diseases.
12. Other traumatic diseases were found during follow-up.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperatively 3 days (post-op D1/2/3), 3 groups of patients with resting pain and active pain in the knee: using VAS score;
- Secondary Outcome Measures
Name Time Method 1 week postoperatively, comparison of knee function scores in 3 groups: HSS score;Differences in drug concentration between blood, knee joint fluid, subcutaneous tissue and deep tissue indomethacin in the three groups on the day of surgery;