Effect of Increased Fruit and Vegetable Intake on Biomarkers of Fruit and Vegetable Consumption
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Change in biomarkers of fruit and vegetable consumption
研究概览
简要总结
This study will examine what contribution of 'markers' of fruit and vegetable (FV) intake in blood and urine is most closely related to FV intake. 30 healthy volunteers will be fed either 2, 5 or 8 portions of FV per day for 4 weeks (ten participants per group, randomly assigned). Volunteers will have all their food provided during the study, and will consume two meals each weekday at the University. Volunteers will complete diet and lifestyle questionnaires at the start and end of the study and will have blood and urine samples collected at 0, 2 and 4 weeks.
详细描述
Single biomarkers of FV consumption, such as Vitamin C and certain carotenoids and flavonoids, have been proposed, but associations between these compounds and FV intake are relatively weak. The investigators propose that, given the complexity of FV, production of an algorithm based on a wide variety of bioactive compounds found in FV might better predict FV consumption. A controlled feeding study (30 volunteers randomised to 2, 5 or 8 portions of FV day for 4 weeks) will allow development of such an algorithm. Volunteers will be recruited by advertisement from QUB and the general public, and will have all their food provided for the 4 week period (two meals per day during the week to be consumed under supervision at the University).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-65 years
- •Usual consumption of fruit and vegetables <= 2 portions/day
排除标准
- •Use of any high dose vitamin, mineral or dietary supplements
- •Current smoker
- •BMI > 35 kg/m2
- •Inability to provide informed consent
- •Excessive alcohol consumption (>28 Units/week men or >21 Units/week women)
- •Food sensitivities or allergies that would interfere with a tolerance of a fruit and vegetable rich diet
- •Medical conditions or dietary restrictions that would substantially limit inability to complete the study requirements
结局指标
主要结局
Change in biomarkers of fruit and vegetable consumption
时间窗: Baseline and 4 weeks
次要结局
未报告次要终点
研究者
Jayne Woodside, PhD
Reader in Clinical Biochemistry
Queen's University, Belfast