Assessment of Anaemia Attributable to Schistosomiasis in School Children in Kenya: Mechanisms and Effect of Treatment

Completed

• Conditions: Anaemia; Schistosomiasis Infection; Malaria; Iron Deficiency
• Interventions: Drug: praziquantl, iron, ACT

• Registration Number: NCT00414479
• Lead Sponsor: DBL -Institute for Health Research and Development

Brief Summary

The purpose of this study is to determine the extend and the nature of anemia in school children and the correlation between anemia and schistosomiasis infections, malaria infections and/or malnutrition (iron deficiency).

Detailed Description

The study will be carried out in an area around Lake Victoria in Kenya where the prevalence of schistosomiasis and malaria are highest in the areas nearest to the Lake. Depending on the prevalence of schistosomiasis a sample of between 876 to 2.524 children will be enrolled in the study. The children who will be in the age between 9 to 12 year, will have their stool and urine examined for schistosomiasis and intestinal worms and a blood sample will be examined for malaria parasites and the hemoglobin level. Children will also be weight, measured and examined by a doctor and register their food intake over one week, to determine their nutritional status. Children who are found to be infected with schistosomiasis, intestinal worms or malaria will be offered treatment. Children who are found to have anemia will be offered a course of iron supplementation, children with severe anemia will be referred to the nearest health facility for treatment. 12 months after the initial examinations and treatment all children will have a re-examination of their stool, urine and blood.

Study Timeline

• Study Start: 2006-07
• Study First Submitted: 2006-12-20
• Study First Submitted QC: 2006-12-20
• Study First Posted: 2006-12-21
• Status Verified: 2010-01
• Primary Completion: 2010-01
• Study Completion: 2010-01
• Last Update Submitted: 2010-01-13
• Last Update Posted: 2010-01-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1500

Inclusion Criteria

• school children between 9 to 12 year

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
children 9-12 years of age	praziquantl, iron, ACT	Children with schistosomiasis, malaria and anaemia

Primary Outcome Measures

Name	Time	Method
hemoglobin level

Secondary Outcome Measures

Name	Time	Method
Schistosomiasis infection
malaria infection
iron deficiency

Trial Locations

Locations (1)

Kenya Medical Research Institute; 🇰🇪 Kisumu, Kenya