Effectiveness of High Intensity Interval Training (HIIT) on Improving Cardiometabolic Health After SCI

Not Applicable

Completed

• Conditions: Cardiovascular Diseases; Metabolic Syndrome

• Registration Number: NCT03808363
• Lead Sponsor: Brock University

Brief Summary

Testing the efficacy of high intensity interval training (HIIT), as compared to current research supporting moderate intensity continuous training (MICT), as a means to improve cardiometabolic health after spinal cord injury.

Detailed Description

This study aims to challenge the effectiveness of the current aerobic exercise recommendations for individuals with spinal cord injuries (SCI). Currently, moderate intensity continuous training (MICT) is suggested however this study intends to explore the effectiveness of high intensity interval training (HIIT). To do so, approximately 8 individuals with SCI will be undergo a 6 week HIIT intervention consisting of 3 sessions per week. With a focus on cardiometabolic health markers (listed in outcome measure section), we aim to provide support for HIIT as a viable method of mitigating cardiovascular risk in a SCI population.

Study Timeline

• Study First Submitted: 2018-10-22
• Study First Submitted QC: 2019-01-16
• Study First Posted: 2019-01-17
• Study Start: 2019-02-01
• Primary Completion: 2019-05-30
• Study Completion: 2019-12-15
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-13
• Last Update Posted: 2020-01-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

• Individuals with a spinal cord injury (paraplegia or tetraplegia, complete or incomplete) who are at least one-year post injury.
• Declared medically stable, and able to communicate clearly in English.

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Waist circumference (inches)	6 weeks	Central adiposity will be measured by tape measure to monitor possible weight loss
Cholesterol	6 weeks	Total and HDL cholesterol will be measured in serum
Triglycerides	6 weeks	Triglycerides will be measured in serum
Glycated Hemoglobin (HbA1c)	6 weeks	Glycated hemoglobin will be measured in whole blood as an indicator of diabetic risk
Tumor necrosis factor (TNF-a)	6 weeks	TNF-a will be used as an inflammatory representative and will be measured in serum
Interleukin - 10 (IL-10)	6 weeks	IL-10 will will be used as an anti-inflammatory representative and will be measured in serum
Adiponectin	6 weeks	Adiponectin will will be used as a surrogate for insulin resistance and will be measured in serum
Blood pressure	6 weeks	Measured through a digital cuff, the focus will be on both systolic and diastolic
Peak Oxygen Consumption (VO2 peak)	6 weeks	VO2 peak will be measured by a Moxus metabolic cart to determine changes in fitness
C Reactive Protein (CRP)	6 weeks	CRP will will be used as an inflammatory representative and will be measured in serum
Leptin	6 weeks	Leptin will will be used as a body fat representative and will be measured in serum
Pulse Wave Velocity	6 weeks	Arterial stiffness, a common measure for cardiac risk will be measured

Secondary Outcome Measures

Name	Time	Method
Physical Activity Enjoyment Scale (PACES)	6 weeks	All participants will complete the physical activity enjoyment scale (PACES) to indicate enjoyment of HIIT. With a total of 18 questions, options 1 through 7 going from a positive to a negative overall experience with the HIIT protocol will be documented.

Trial Locations

Locations (1)

Brock University; 🇨🇦 St. Catherines, Ontario, Canada