Free Vitamin D Correlate Better With BMD and Fracture Than Total Serum Vitamin D?
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 125
- 试验地点
- 1
- 主要终点
- Free vitamin D
研究概览
简要总结
According to the free hormone hypothesis, the biological activity of a hormone is carried by the portion that is not bound to protein or its carrier in circulation. Based on this, we believe that the free vitamin d, which is the proportion of Vitamin D unbound to vitamin D binding protein and albumin, performs the calcium-regulating functions of the vitamin. Hence, our objective is to study whether free vitamin correlated better with BMD and fracture than the total vitamin D.
详细描述
Osteoporosis is a major health issue worldwide as it increases the risk of fragility fracture and chronic disability. The studies on the association between vitamin d and osteoporosis have yielded conflicting results. While some have shown a positive correlation, others have concluded that there is no association at all. Recent reports have shown vitamin D supplementation do not prevent fragile fractures. This might be because the actual vitamin D status, which should be the free vitamin D, has not been measured.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 48 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with a diagnosis of osteoporosis and with or without fracture
- •post- menopausal women
- •age > 48 years
排除标准
- •vitamin D supplementation in recent 6 months
- •patients on steroid
- •age < 48 years
- •patients with chronic diseases such as liver cirrhosis, renal failure, hypertension, hyperparathyroidism
研究组 & 干预措施
free vitamin d
free vitamin is directly measured from blood serum using an ELISA kit
干预措施: free vitamin d test (Diagnostic Test)
total vitamin d
Total vitamin d is measured routinely from blood serum
干预措施: total vitamin d (Diagnostic Test)
结局指标
主要结局
Free vitamin D
时间窗: ! day
measured using free vitamin D Elisa kit
Total vitamin D
时间窗: ! day
It is measured as a part of routine investigation at the time of admission
次要结局
- BMD(! day)
- Vertebral fracture(! day)
研究者
Limin Rong
professor, department of spine surgery
Third Affiliated Hospital, Sun Yat-Sen University