Acute Effects of Resistance Training with Cluster Sets in Adults with Charcot-Marie-Tooth Disease

Not Applicable

Recruiting

• Conditions: Charcot-Marie-Tooth Disease; Fatigue; Reduced physical function; Neurological - Neurodegenerative diseases; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12622001574730
• Lead Sponsor: The University of Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-12-20
• Last Update Posted: 27 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

To be included in this study individuals need to be clinically diagnosed with Charcot-Marie-Tooth disease (CMT) based on genetic and electrophysiological data. Participants need to be free of rotator cuff tear or history of any shoulder or back or lower extremity condition, injuries, surgeries, congenital malformations, back, knee, or hip osteoarthritis, recent fracture (12 months), cognitive impairment as defined by Montreal Cognitive Assessment score of 27-30, acute or terminal illness and any unstable or ongoing cardiovascular/respiratory disorders.

Exclusion Criteria

Individuals with morbid obesity (BMI > 40) will also be excluded since thick subcutaneous fat might impair NIRS outcomes. Participants that cannot speak English. People will be excluded if they are not sufficiently ambulatory (defined as the inability to walk 100 m in under 4 minutes).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Muscle force assessed by Keiser pneumatic equipment.[ Monitored continuously throughout resistance exercise.];Muscle power output assessed by Keiser pneumatic equipment.[ Monitored continuously throughout resistance exercise.];Velocity assessed by Keiser pneumatic equipment.[ Monitored continuously throughout resistance exercise.]