Evaluation of Ultrahigh-Field-MRI at 7 Tesla for Imaging of ischemic lesions, carotid plaque morphology and brain perfusion - 7 UP

Recruiting

• Conditions: I63.9; I65.2; Cerebral infarction, unspecified; Occlusion and stenosis of carotid artery

• Registration Number: DRKS00003193
• Lead Sponsor: Charité Campus Charité Mitte

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-08-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

General inclusion criteria:

-Stable patient condition not requiring in-hospital treatment
-Age: 18 – 80 years
-Preserved ability to give informed consent
-Informed consent
-Legal competence

Specific inclusion criteria

-sub-project 1:
oTIA
oCortical/sub-cortical infarcts

-sub-project 2:
ointernal or communal carotid artery stenosis (>50%) or as shown by Doppler sonography

-sub-project 3:
ointernal carotid artery stenosis (>70%) or occlusion as shown by Doppler sonography

Exclusion Criteria

-cardiac pacemaker or any other magnetic implant
-every kind of metallic or electro-(magnetic) implant
-pregnancy and breastfeeding period
-claustrophobia
-chronic or episodic vertigo
-diseases of the retina (e.g. retinal detachment or macula degeneration)

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
part 1:<br><br>Number of microinfarcts after clinically proven transient ischemic attack, identified by 7 Tesla magnetic resonance imaging (MRI) in comparison to 3 Tesla MRI <br><br>part 2:<br><br>Discriminability of core and cap in carotid plaques at 7 Tesla in comparison to 3 Tesla.<br><br>part 3:<br><br>Perfusion measurement by ASL at 7 Tesla in comparison to 3 Tesla.<br>