The Effects of Physical Exercise Training in Patients With Chronic Obstructive Pulmonary Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Rigshospitalet, Denmark
- Enrollment
- 30
- Locations
- 2
- Primary Endpoint
- Skeletal muscle function
Study Overview
Brief Summary
The purpose of the present project is to investigate the physiological effects of two different types of exercise training in COPD patients. The patients will be examined before, during and after 8 weeks of training to evaluate the effect of different types of skeletal muscle stimulation on health related quality of life, 6 min walking distance, flow mediated dilation, and histological properties of skeletal muscle cells, regarding oxidative capacity, fiber type, purinergic receptor amounts and measures of systemic inflammation. The study will test the hypothesis that:
Resistance training is superior to endurance training in patients with COPD
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 40 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •FEV1/FVC fixed ratio <0.70, FEV1: <60% of predicted and MRC > or equal to 3
- •Arterial oxygen saturation at rest> 90%, BMI >18, LVEF>
- •Age: 40 - 80 years
- •The medical treatment will be continued unchanged during the study and additional prednisolone and /or antibiotic treatment will be prescribed in case of acute exacerbation.
Exclusion Criteria
- •Unstable ischemic heart disease, severe heart valve failure, pulmonary emboli, severe heart failure, severe infections, musculoskeletal disorders, malignant disease, contraindicated medicine as MAO inhibitors and anticoagulants.
Arms & Interventions
Patients with COPD
Patients with COPD are to be trained 3 times a week for 8 weeks
Intervention: Resistance training (Behavioral)
Control patients with COPD
Control patients with COPD are to be trained 3 times a week for 8 weeks
Intervention: Endurance training (Behavioral)
Outcomes
Primary Outcomes
Skeletal muscle function
Time Frame: At baseline and after 8 weeks of traning
Muscle biopsy
Secondary Outcomes
- Flow mediated dilation(Change from baseline at 8 weeks)
- Body composition(Change from baseline at 8 weeks)
- 6 min walking test(Change from baseline at 8 weeks)
- Health Related Quality of Life - COPD assessment test (CAT)(Change from baseline at 8 weeks)
Investigators
Anders Rasmussen Rinnov
Administrator
Rigshospitalet, Denmark