Partial Pleurectomy (Surgery) for Unresectable Pleural Mesothelioma

Not Applicable

Not yet recruiting

• Conditions: Mesothelioma; Mesothelioma Malignant Advanced; Mesothelioma, Malignant; Mesothelioma; Lung; Mesotheliomas Pleural

• Registration Number: NCT07126509
• Lead Sponsor: University of Chicago

Brief Summary

Purpose of the study: The main purpose of this research study is to see if a surgery procedure (limited partial pleurectomy and decortication) helps symptoms in people who have cancer that is unresectable that might not be able to be removed completely. This is called unresectable cancer. This study will also help the research team learn more about the types of symptoms and quality of life for people who have undergone this surgery, the number of complications following , and the time from surgery to starting other therapy. Th e study team also wants to see see the overall survival of people who have had this procedure as part of their care.

What will be done as part of research on this study:

* Surgery (Partial Pleurectomy - surgery to remove lining of lungs)

* The research team will also ask study participants questions about their symptoms through questionnaires at certain times after surgery.

How long this study will last:

Participation in this research (pre-surgery, surgery and follow-up) will last for about 2 years.

Confidentiality: All personal information will be kept confidential, and data will be used only for research purposes.

Contact Information: For more information about this study, please contact PhaseIICRA@medicine.bsd.uchicago.edu

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-08
• Study First Submitted: 2025-08-11
• Study First Submitted QC: 2025-08-11
• Last Update Submitted: 2025-08-11
• Study First Posted: 2025-08-17
• Last Update Posted: 2025-08-17
• Study Start: 2025-12-01
• Primary Completion: 2028-12-01
• Study Completion: 2028-12-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Disease-related Symptom Burden 3 Months After Partial Pleurectomy (Surgery)	3 months after surgery	The primary objective is to assess the post-operative disease-related symptom burden in participants undergoing partial pleurectomy and decortication for borderline or unresectable pleural mesothelioma, as measured by the mesothelioma-specific Lung Cancer Symptom Scale Average Symptom Burden Index (LCSS-meso ASBI) at 3 months post-surgery.

Secondary Outcome Measures

Name	Time	Method
Quality of Life of Study Participants Who Have Undergone Partial Pleurectomy (Surgery)	2 years	To longitudinally evaluate quality of life in patients who have undergone partial pleurectomy and decortication as assessed by quality of life questionnaires and patient reported outcomes.
Rate of Complications after Partial Pleurectomy (Surgery)	2 years	To estimate the rate of complications following partial pleurectomy and decortication as assessed by treating investigator and clinical notes.
Time to Resumption of Systemic Therapy	2 years	To determine time to resumption of systemic therapy following partial pleurectomy and decortication as assessed by treating investigator and clinical notes.
Overall Survival of Study Participants Who Have Undergone Partial Pleurectomy (Surgery)	2 years	To estimate overall survival in participants who have undergone partial pleurectomy and decortication as assessed by treating investigator and clinical notes.