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Clinical Trials/NCT04954482
NCT04954482
Completed
N/A

Anatomical and Biomechanical Study of Combined Reconstruction in the Treatment of III° Posterior Cruciate Ligament Injury

Peking University Third Hospital1 site in 1 country14 target enrollmentApril 11, 2017

Overview

Phase
N/A
Intervention
Not specified
Conditions
Posterior Cruciate Ligament Tear
Sponsor
Peking University Third Hospital
Enrollment
14
Locations
1
Primary Endpoint
The distance of posterior displacement of the tibia
Status
Completed
Last Updated
4 years ago

Overview

Brief Summary

To establish a III°PCL injury model on fresh cadaver knee specimens, and to define the pathological and anatomical connotation of III°PCL injury by using anatomical methods.

To explore and establish combined reconstruction techniques, including PCL reconstruction combined with injury repair and reconstruction, and to explore the role of combined reconstruction techniques in maintaining knee stability through biomechanical experiments.

Detailed Description

Objective: (1) To establish a III°PCL injury model on fresh cadaver knee specimens, and to define the pathological and anatomical connotation of III°PCL injury by using anatomical methods. (2) To explore and establish combined reconstruction techniques, including PCL reconstruction combined with injury repair and reconstruction, and to explore the role of combined reconstruction techniques in maintaining knee stability through biomechanical experiments. Design: ① The subjects of this study were fresh cadaver knee specimens. * Sample size: A Anatomical study of injury model, planning 6 cases. B. Exploration of treatment methods for complicated injuries. 8 cases of specimens are planned to be used. According to the pathological and anatomical content of III°PCL injury (IKDC standard), the repair and reconstruction techniques of combined injury were designed. Arthroscopic transtibial single-bundle PCL reconstruction technique was used in all the reconstruction of PCL. Using the robotic arm or universal sensor test system as the biomechanical test platform, Biomechanical tests were carried out on the experimental specimens, and the results were compared to determine the shortcomings of the new PCL reconstruction, according to which the surgical procedures were improved, and then the biomechanical tests were carried out. After repeated technical improvement (4 cycles, 2 specimens per cycle), the new PCL reconstruction technique was finally determined. C To investigate the effect of new PCL reconstruction in maintaining the stability of knee joint, 8 cases were treated with a specimen plan. Biomechanical tests were performed on each specimen in its intact state, post-traumatic state (after the establishment of the III°PCL injury model), and post-traumatic state (after the application of the new PCL reconstruction technology) using the robotic arm/universal sensor test system. Outcome evaluation: The biomechanical characteristics of knee specimens under different conditions were measured, compared and statistically analyzed, and the conclusions were drawn. Statistical Methods: * Multivariate linear analysis model and Bonferroni multiple comparison were used to compare the kinematics changes of knee joints under various loading conditions and knee flexion angles under the condition of knee joint integrity, III°PCL injury, PCL reconstruction, and combined injury treatment. * Univariate repeated measure ANOVA was used to compare the knee joint integrity, III°PCL injury, the stability of the knee joint after PCL reconstruction, and the stability of the knee joint after combined injury treatment (including the back drawer test and stress radiograph measurement).

Registry
clinicaltrials.gov
Start Date
April 11, 2017
End Date
June 23, 2019
Last Updated
4 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Liu Ping

chief physician

Peking University Third Hospital

Eligibility Criteria

Inclusion Criteria

  • no sports injuries such as knee ligament rupture and meniscus injury specimens

Exclusion Criteria

  • sports injuries such as knee ligament rupture and meniscus injury specimens

Outcomes

Primary Outcomes

The distance of posterior displacement of the tibia

Time Frame: On the day of enrollment.

The robotic arm/universal sensor test system was used as the test platform to test the specimens .

Secondary Outcomes

  • Tibial valgus Angle(On the day of enrollment.)
  • Internal rotation angle of the tibia(On the day of enrollment.)
  • External rotation angle of the tibia(On the day of enrollment.)
  • Tibia varus Angle(On the day of enrollment.)

Study Sites (1)

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