Effects of Acute Glycerol Ingestion on Performance, Metabolic and Biochemical Markers in International Athletes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 4
- 试验地点
- 2
- 主要终点
- Body weight
研究概览
简要总结
This clinical study evaluates the acute effect of glycerol ingestion on performance (power output), weight, urine specific gravity, biochemical (antioxidants and lactate) and metabolic (indirect calorimetry) markers in international athletes in hot conditions. The investigators hypothesized that acute glycerol ingestion can prevent performance loss (power generated at submaximal intensity) in hot conditions. To justify this hypothesis, the investigators will measure the aforementioned markers, which could establish a cause-effect relationship between acute glycerol intake and decreased performance loss in hot conditions.
详细描述
All participants will be informed about the procedures and provide signed informed consent. The study will be conducted according to the guidelines of the Helsinki Declaration for Human Research and the protocol was approved by the Ethics Committee/Institutional Review Catholic University of Murcia (Code: CE091802).
Study design
This is a randomized crossover study. There are 3 types of intervention: water intake of 26 mL/kg/weight at 16°C (CON), 26 mL/kg/weight + placebo at 28°C (PLA) and intake of 1.2 g glycerol + 26 mL/kg/weight at 28°C (GLY). In addition, athletes will be instructed to take a individualized diet in relation to macronutrients (verified by dietary record) and they will follow their adjusted training schedule so that there would be no effect on the tests. Participants in both groups will be instructed not to consume supplements 3 weeks prior to the start of the study.
Procedures
Participants will visit the laboratory on five occasions. Visit 1 consists of a medical examination and a blood draw to determine health status. At visit 2, after a dinner the night before and a standard breakfast, an incremental test will be performed to determine the exercise zones in the rectangular test. At visits 3, 4 and 5, a record of the diet (individually set) will be performed regarding the former 7 days, followed by a rectangular treadmill test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 25 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Be an international athlete with the Spanish national athletics team.
排除标准
- •Are smokers or regular alcohol drinkers,
- •Have a metabolic, cardiorespiratory or digestive pathology or anomaly,
- •Have an injury in the prior 6 months
- •Are supplementing or medicating in the prior 2 weeks
- •Have non-normal values in the blood analysis parameters.
结局指标
主要结局
Body weight
时间窗: Throughout study completion, an average of 3 weeks
Record body weight before and after the rectangular test
Body temperature
时间窗: Throughout study completion, an average of 3 weeks
Record body temperature by thermography of the head, trunk, and lower limbs, anterior and posterior in rest, after 5th and 10th series, and after completion of the rectangular test
Urine specific gravity
时间窗: Throughout study completion, an average of 3 weeks
Record urine specific gravity by means a digital refractometer (Atago) before and after the rectangular test
Power output
时间窗: Throughout study completion, an average of 3 weeks
Record the power produced by means the stryd sensor (shoe) in the 1st, 5th, 10th and 15th series of the rectangular test
次要结局
- Measurement of fast- and slow-acting antioxidants (Q1 and Q2) and total antioxidant capacity by a portable analyzer eBQC0101(Throughout study completion, an average of 3 weeks)
- Heart rate(Throughout study completion, an average of 3 weeks)
- VE(Throughout study completion, an average of 3 weeks)
- Lactate(Throughout study completion, an average of 3 weeks)
- Ground contact time(Throughout study completion, an average of 3 weeks)
- FAT ox(Throughout study completion, an average of 3 weeks)
- VO2/R(Throughout study completion, an average of 3 weeks)
- VO2(Throughout study completion, an average of 3 weeks)
- RER(Throughout study completion, an average of 3 weeks)
- Cadence(Throughout study completion, an average of 3 weeks)
- PO/R(Throughout study completion, an average of 3 weeks)
- HC ox(Throughout study completion, an average of 3 weeks)
- EE(Throughout study completion, an average of 3 weeks)
- V'E/V'O2(Throughout study completion, an average of 3 weeks)
- Leg spring stiffness(Throughout study completion, an average of 3 weeks)
- CO2(Throughout study completion, an average of 3 weeks)
- FR(Throughout study completion, an average of 3 weeks)
- V'E/V'CO2(Throughout study completion, an average of 3 weeks)
- Form power ratio(Throughout study completion, an average of 3 weeks)
- Form power(Throughout study completion, an average of 3 weeks)
- Vertical oscillation(Throughout study completion, an average of 3 weeks)
研究者
Francisco Javier Martínez Noguera
Study coordinator (Investigator)
Universidad Católica San Antonio de Murcia