Acute Effects of Propylene Glycol/Glycerol Intake on Cardiorespiratory Blood Parameters
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Cardiorespiratory biological variables
研究概览
简要总结
The aim of this study is to evaluate the acute effect of propylene glycol and glycerol intake on cardiorespiratory blood parameters.
详细描述
Background : Propylene glycol/glycerol intake is increasingly popular. Acute effect of propylene glycol and glycerol intake on cardiorespiratory blood parameters is unknown. The investigators postulate that intake of propylene glycol and glycerol could modifiy cardiorespiratory blood parameters.
Aims of this study : to test the following hypotheses :
- Acute intake of propylene glycol and glycerol modifies cardiorespiratory blood parameters.
To test this hypothesis, we will perform blood samples before and after intake of propylene glycol and glycerol. Participants will be tobacco smoker between 18 and 70 years old, with multiple cardiovascular risk factors, and who will undergo a cardiac catherization. After the cardiac catherization, the catheter will be used to perform serial blood samples.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subject undergoing cardiac catherization
- •Subject must be an active tobacco smoker
排除标准
- •Symptoms of infection or inflammation
- •Acute disease including heart rhythm disorder, acute coronary syndrome or decompensation of a chronic disease (heart failure, COPD,...)
- •Unexpected and undesirable effects during the cardiac catherization procedure
- •Respiratory failure requiring supplementary oxygen
研究组 & 干预措施
Propylene glycol and Glycerol intake
One gram intake of a Propylene glycol/Glycerol mix (50:50)
干预措施: Propylene glycol and Glycerol intake (Other)
Mimicking intake
Mimicking Propylene glycol/Glycerol intake with the device turns off
干预措施: Mimicking intake (Device)
结局指标
主要结局
Cardiorespiratory biological variables
时间窗: 5 minutes
Blood sample
次要结局
- Cardiorespiratory biological variables(20 minutes)
研究者
Martin Chaumont
MD, Cardiology Fellow
Université Libre de Bruxelles