Reversibility of Propylene Glycol/Glycerol Intake Effects on Cardiorespiratory Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Change in cardiorespiratory function
研究概览
简要总结
Propylene glycol/Glycerol intake is increasingly popular. The propylene glycol/glycerol intake effects on cardiorespiratory function are unknown.
详细描述
Background. Propylene glycol/Glycerol intake is increasingly popular. The propylene glycol/glycerol intake effects on cardiorespiratory function are unknown. Weaning of propylene glycol/glycerol could allows a quick clearance of propylene glycol/glycerol from the body, with subsequent recovery of cardiorespiratory function.
Specific aim of the research. This research proposal tests the following hypothesis regarding the reversibility of propylene glycol/glycerol and nicotine intake:
- Propylene glycol/glycerol cessation restores cardiorespiratory function.
- Chronic propylene glycol/glycerol and propylene glycol/glycerol/nicotine intake induces specific serum and urine proteomics profile, which are partially reversed after cessation.
- Chronic propylene glycol/glycerol and propylene glycol/glycerol/nicotine intake induces specific serum and urine metabolomics profile, which are partially reversed after cessation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Subject must be regular propylene glycol/glycerol/nicotine intake users since at least 1 year
- •Subject must be former smokers
排除标准
- •Chronic or acute illness
- •Substance abuse
- •Chronic medication intake
结局指标
主要结局
Change in cardiorespiratory function
时间窗: 4 hours
Continuous monitoring of cardiorespiratory function
次要结局
- Change in serum and urine proteomics profiles(1 hour)
研究者
Martin Chaumont
Principal investigator
Université Libre de Bruxelles