NL-OMON54140招募中不适用
The neurobiological correlates of anhedonic depression in Parkinson*s disease; associations between dopamine function and functional pathways - AnHedonic dEpression&Alteration in Dopamine-neurocircuit in Parkinson:AHEAD
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 75
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •For the present study, we will select patients from the PPP and PRIME cohorts
- •and from clinical samples from neurologists embedded in Parkinsonnet and/or in
- •the service area of the RadboudUMC. The PPP study is a pro-spective,
- •longitudinal, single-center cohort study of the Radboudumc in the Netherlands
- •which started in October 2017. Enrollment period will take 2 years, in which a
- •total of 650 adult patients diagnosed with PD with <=5 years duration will be
- •included. PRIME is a prospective longitudinal study of the RadboudUMC of the
- •Netherlands which started in 2019 and enrolls 1200 patients with either
- •clinically diagnosed PD or parkinsonism.
- •ParkinsonNet is an innovative health care concept that consists of 70
- •professional networks for PD covering all of the Netherlands
- •In order to be eligible to participate in this study, a subject must meet all
- •of the following criteria:
- •A diagnosis of PD with <=10 years duration, defined as time since diagnosis
- •made by a neurologist.
- •Subject can read and understand Dutch.
- •Subject is willing, competent, and able to comply with all aspects of the
- •meeting DSM-criteria for a depression including the criterium of a sad mood
- •(depressed PD group)
- •in the 5 past years and/or currently not meeting DSM-criteria for a
- •depression (non-depressed PD control group)
排除标准
- •A potential subject who meets any of the following criteria will be excluded
- •from participation in this study:
- •Contraindications for MRI, e.g., claustrophobia, presence of an active
- •implant, pacemaker, insulin pump, neurostimulator, ossicle prosthesis,
- •pregnancy, and/or other medical device or other non-removable metal part
- •incompatible with MRI.
- •Contraindications for PET e.g., inability to lie flat or lie still for the
- •duration of the scan, claustrophobia (occasionally).
- •Use of medication or drugs with evident DAT-binding like methylphenidate,
- •buproprion, amphetamines, cocaine that cannot be discontinued according to the
- •PET-protocol. Note that we allow use of anti-depressants with the exception of
- •those antidepressants with a high DAT binding defined as a relatively low Ki of
- •<1000 (, i.e. for the Netherlands buproprion, duloxetine and sertraline).
- •Moreover, we will exclude patients using antidepressants at higher than minimal
- •effective dosages used for antidepressive effects when the Ki is <10000 (i.e.
- •for the Netherlands amitryptiline, clomipramine, maprotiline, nortriptyline,
- •fluoxetine, paroxetine).
- •Being diagnosed with dementia (defined as a Montreal Cognitive Assessment
- •(MoCA) <21/30 (Dalymple-Alford 2010), assessed ON Parkinson medication).
- •Psychiatric diagnosis of bipolar disorder.
- •Presence of current psychotic symptoms.
研究者
相似试验
尚未招募
不适用
Anhedonic depression and alterations in the dopaminergic neurocircuitry in Parkinson’s diseaseParkinson's Disease, Depression, AnhedoniaNL-OMON26572RadboudUMC Nijmegen, Department of Psychiatry75
已完成
不适用
A Neurobiological Model of AnhedoniaAnhedoniaDepressionNCT05629520Milton S. Hershey Medical Center60
已完成
2 期
Pramipexole to Target "Anhedonic Depression"Depression, BipolarDepression, UnipolarAnhedoniaDysthymiaNCT04121091Region Skane13
终止
4 期
Imaging the Nucleus Accumbens in Major Depressed Patients 'Treated With PramipexoleDepressionNCT01066897Stanford University16
已完成
不适用
The influence of depression and neuroinflammation on the progression of mild cognitive impairment to dementia: PET imaging of amyloid deposition and microglia activatiolate onset depressionMild cognitive impairment1004225810012272NL-OMON32861niversitair Medisch Centrum Groningen48